Medication Guide for Inderal

Active Ingredient Details

Inderal contains the active ingredient propranolol, a non-selective beta-adrenergic receptor blocker. This component is utilized for its ability to inhibit the beta-adrenergic receptors throughout the body.

Pharmacological Action Mechanism

Inderal reduces heart rate, blood pressure, and strain on the heart by blocking beta-adrenergic receptors in the heart and peripheral vasculature. This leads to decreased cardiac output through diminished sympathetic nervous system activity.

Common Indications

Inderal is commonly prescribed for hypertension, angina pectoris, and arrhythmias. It is also indicated for myocardial infarction, migraine prophylaxis, and specific anxiety disorders.

Dosage Forms Availability

Inderal is available in various dosage forms, including tablets, extended-release capsules, and oral solutions. The range of available doses allows for precise administration tailored to individual patient needs.

Standard Dosage Regimens

Typical dosages for hypertension start at 40 mg twice daily. For angina, an initial dose of 80 mg per day is common. Dosage adjustments are often necessary based on therapeutic response and tolerance.

Administration Guidelines

Inderal should be taken consistently either with food or on an empty stomach. It is important to swallow extended-release capsules whole without crushing or chewing.

Metabolism and Excretion

Inderal is metabolized primarily in the liver by cytochrome P450 enzymes, particularly CYP2D6. It is excreted through the kidneys, with a half-life of approximately 3 to 6 hours for immediate-release formulations.

Potential Drug Interactions

Co-administration with other antihypertensives can potentiate blood pressure-lowering effects. Caution is advised when taken with antiarrhythmics, as it can exacerbate effects on heart rate and rhythm. Avoid combining with MAO inhibitors due to possible hypertensive reactions.

Adverse Effect Profile

Common adverse effects include bradycardia, fatigue, and dizziness. In rare cases, Inderal can induce bronchospasm, particularly in patients with asthma or other respiratory conditions. Other potential side effects include gastrointestinal disturbances and cold extremities.

Special Population Considerations

In elderly patients, dosages may need to be reduced due to decreased hepatic, renal, and cardiac function. For pediatric use, consult specialized guidelines, as dosing must be carefully adjusted based on weight and condition.

Storage Recommendations

Store Inderal at room temperature, away from excessive humidity and heat. Keep the medication in its original packaging to protect it from light and moisture.

Monitoring Parameters

Regular monitoring of blood pressure and heart rate is essential. Liver function tests may be necessary due to hepatic metabolism. Periodic ECGs can aid in identifying potential arrhythmias.