Brand and Generic Names

Dramamine is the brand name. The generic name is dimenhydrinate. Available forms include tablets, chews, and liquid. Each form varies in strength and dosage.

Drug Class

Dramamine belongs to the antihistamine class. Specifically, it falls under the subcategory of antiemetics. Antiemetics are used to treat nausea and vomiting. Antihistamines work by blocking histamine receptors in the brain.

Available Dosages

Dramamine is available in multiple dosages. Common strengths include 25 mg and 50 mg tablets. Liquid form typically has 12.5 mg per 5 mL. Chewable tablets often come in 50 mg strength. Dosages may vary based on age, weight, or medical condition.

Indications for Use

Primarily indicated for motion sickness. Also prescribed for vertigo and nausea. Effective for symptoms related to vestibular dysfunction. Some use it off-label for anxiety-related nausea. Never self-diagnose or adjust dosage without consulting a healthcare professional.

Mechanism of Action

Dimenhydrinate works by blocking H1 receptors. Reduces stimulation of the vestibular system in the brain. This action helps control nausea and vomiting. Anticholinergic effects help reduce signals from the vestibular system to the vomiting center in the brain.

Pharmacokinetics

Absorption occurs rapidly from the gastrointestinal tract. Peak plasma levels reached within 1-2 hours. The half-life ranges between 3.5 to 9 hours. Metabolized primarily in the liver. Excreted through urine as conjugated metabolites.

Proper Administration

Take tablets with water. Chewables should be thoroughly chewed before swallowing. The liquid form should be measured with a proper dosing spoon. Take 30-60 minutes before travel for motion sickness prevention. Avoid crushing or splitting tablets unless specified by a doctor. Follow prescribed dosage exactly.

Missed Dose

If you miss a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed dose. Do not double doses to make up for missed ones. Maintain a consistent schedule to avoid missed doses. Consult your healthcare provider for further instructions.

Storage Instructions

Store at room temperature, away from moisture and heat. Keep out of reach of children. Do not store in the bathroom. Check expiration date regularly. Dispose of expired medication responsibly.

Drug Interactions

Dimenhydrinate can interact with other CNS depressants. Increased sedative effect when combined with alcohol, benzodiazepines, or opioids. Avoid combining with monoamine oxidase inhibitors (MAOIs). Anticholinergic effects may be increased when taken with tricyclic antidepressants. Consult your doctor for a complete list of drug interactions.

Common Side Effects

Drowsiness is the most common side effect. Other side effects include dry mouth, blurred vision, and constipation. Some individuals experience dizziness or headache. Children may experience an excitatory reaction. Report any persistent or bothersome side effects to your healthcare provider.

Severe Side Effects

Severe side effects are rare but require immediate medical attention. These include difficulty urinating, irregular heartbeat, severe dizziness, or breathing difficulties. Increased intraocular pressure may exacerbate glaucoma symptoms. Seek immediate medical help if severe side effects occur.

Precautions and Contraindications

Avoid use if allergic to dimenhydrinate or its components. Cautious use in patients with asthma, glaucoma, or an enlarged prostate. Not recommended during pregnancy unless prescribed. Advise caution in elderly patients due to increased risk of dizziness and falls. Monitor for signs of overdose and misuse.

Pediatric Use

Approved for use in children over two years old. Dosage differs based on age and weight. Often provided in liquid form for accurate dosing. Chewable tablets should be used for older children. Consult a pediatrician before administration.

Geriatric Use

Increased sensitivity to side effects such as sedation. May require lower dosages. Greater risk of falls due to dizziness or drowsiness. Regular assessment of renal and hepatic function recommended. Consult a healthcare provider for tailored advice.

Dietary Considerations

Avoid alcohol as it increases drowsiness. Maintain adequate hydration. High-fat meals may delay absorption. No significant dietary restrictions. Consult a healthcare provider for personalized dietary advice.

Monitoring and Follow-Up

Regular follow-ups recommended to assess effectiveness. Monitor for side effects and adverse reactions. Blood pressure and pulse checks may be advised. Report any unexpected symptoms or concerns to your healthcare provider. Adjustments in dosage may be necessary based on response and tolerance.

Patient Counseling

Educate patients on proper usage and dosage. Discuss potential side effects. Advise against alcohol consumption during treatment. Inform of the importance of sticking to prescribed dosage. Encourage monitoring of personal response and side effects.