Aldactone

Aldactone’s active ingredient is spironolactone. Alternative names for Aldactone include CaroSpir. It is used to treat conditions like high blood pressure, heart failure, and fluid retention (edema). Additionally, Aldactone can help with hormonal acne and certain hormone-related conditions.

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Aldactone Price

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A pack of Aldactone can cost anywhere between £0.59 and £1.01. The exact price depends on pack measurements and active ingredient density (30 or 360 mg).

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Medication Overview

Aldactone, generically known as spironolactone, is a potassium-sparing diuretic. It is primarily utilized to treat conditions related to excessive fluid retention such as heart failure, hypertension, and certain liver and kidney diseases.

Dosage Forms Available

Aldactone is available in tablet form. The tablets come in dosages of 25 mg, 50 mg, and 100 mg. The dosage strength is selected based on the specific medical condition being treated and the patient’s overall health status.

Pharmacological Class

Aldactone belongs to the class of medications known as potassium-sparing diuretics. It works by causing the kidneys to eliminate excess sodium and water from the body while retaining potassium. This mechanism helps reduce fluid buildup and lowers blood pressure.

Indications for Use

Aldactone is prescribed for managing edema in congestive heart failure, cirrhosis of the liver with ascites, and nephrotic syndrome. It is also used in treating primary hyperaldosteronism and essential hypertension not controlled by other medications.

Heart Failure Management

In heart failure cases, Aldactone helps prevent the worsening of symptoms by reducing fluid overload, thus easing the workload on the heart. Its use has been shown to improve survival rates in such patients.

Hypertension Treatment

Aldactone is employed when hypertension is not adequately controlled with other therapies. It works along with other antihypertensive drugs to maintain optimal blood pressure levels.

Liver Cirrhosis Application

For patients with liver cirrhosis, Aldactone helps manage ascites by promoting fluid excretion. This alleviates abdominal swelling and discomfort associated with fluid overload.

Mechanism of Action

Spironolactone works by antagonizing the actions of aldosterone, a hormone that promotes sodium and water retention. By inhibiting aldosterone, Aldactone enhances sodium excretion and potassium reabsorption, resulting in diuresis and natriuresis.

Administration Guidelines

Aldactone should be taken orally, with or without food, as directed by a healthcare provider. Consistency is key; it should be taken at the same time each day. Dosage may need adjustment based on response and blood test results.

Initial Dosing

The initial dosage for adults typically ranges from 25 to 100 mg per day, administered in single or divided doses. The exact dosage depends on the condition being treated and individual patient factors.

Maintenance Dosing

Maintenance doses are often adjusted based on the patient’s response and tolerance. For severe cases of hyperaldosteronism, doses may be gradually increased up to 400 mg daily, based on clinical response.

Monitoring Requirements

Regular monitoring of electrolytes, kidney function, and blood pressure is essential while on Aldactone. Periodic blood tests help prevent hyperkalemia and renal impairment.

Potassium Levels

Because Aldactone retains potassium, frequent monitoring of serum potassium levels is crucial. Elevated potassium levels can lead to serious complications, especially in patients with renal impairment.

Renal Function

Assessing renal function is important before initiating treatment and periodically during therapy. Patients with impaired renal function require cautious dosing adjustments to prevent adverse effects.

Potential Drug Interactions

Aldactone can interact with various medications, enhancing the risk of adverse effects or reducing therapeutic efficacy. Physicians must review patient medication histories for potential interactions.

ACE Inhibitors

Combining Aldactone with ACE inhibitors can lead to hyperkalemia due to synergistic potassium-sparing effects. Monitoring potassium levels becomes even more critical in such cases.

NSAIDs Interaction

Non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the diuretic efficacy of Aldactone and increase the risk of renal impairment. Patients should be advised to avoid or use NSAIDs with caution.

Lithium Interaction

Concurrent use of lithium and Aldactone may increase serum lithium levels, risking lithium toxicity. Frequent lithium level monitoring is advised if both drugs are prescribed.

Digoxin Interaction

Aldactone may enhance the effects of digoxin by reducing renal clearance, leading to digoxin toxicity. Patients on both medications should undergo regular digoxin level monitoring.

Specific Patient Groups

Special consideration must be given to various patient groups when prescribing Aldactone, including the elderly, pregnant or breastfeeding women, and patients with specific medical conditions.

Elderly Patients

Elderly patients are more prone to kidney function impairment and electrolyte imbalances. Lower starting doses and careful monitoring are recommended to minimize risk.

Pregnancy and Lactation

The safety of Aldactone during pregnancy and lactation is not firmly established. Potential benefits should be weighed against potential risks to the fetus or breastfeeding infant.

Renal Disease Patients

Patients with renal disease require extra caution due to the risk of hyperkalemia and decreased renal excretion. Dosages should be adjusted and closely monitored.

Adverse Effects

While Aldactone is effective, it can cause side effects that range from mild to severe. Patients should be informed about potential adverse effects and advised to report any unusual symptoms.

Common Side Effects

Common side effects include dizziness, headache, gastrointestinal disturbances such as nausea or vomiting, and menstrual irregularities. Most side effects are dose-related and may resolve upon dosage adjustment.

Serious Side Effects

Serious side effects include hyperkalemia, renal failure, and allergic reactions. Patients experiencing symptoms like muscle weakness, irregular heartbeat, or severe rash should seek immediate medical attention.

Endocrine Effects

Endocrine effects such as gynecomastia in men and menstrual irregularities in women can occur due to Aldactone’s anti-androgen effects. These side effects may necessitate discontinuation of therapy.

Storage Instructions

Aldactone should be stored at room temperature, away from light and moisture, in its original container. It must be kept out of reach of children and pets. Do not use tablets past their expiration date.

Proper Disposal

Unused or expired Aldactone should be disposed of properly, not flushed down the toilet or poured into drains. Pharmacies often provide medication take-back programs.

Patient Counseling Points

Patients should be counseled on the importance of adhering to prescribed dosages and maintaining regular check-ups. They should be made aware of potential side effects and advised to avoid potassium-rich foods and supplements.

Lifestyle Modifications

Encouraging lifestyle modifications such as dietary adjustments and regular physical activity can enhance the therapeutic effects of Aldactone for managing conditions like hypertension and heart failure.

Hydration Advice

Patients should maintain adequate hydration but avoid excessive fluid intake to prevent electrolyte imbalances. They should be instructed to recognize signs of dehydration or overhydration.

Dosage

100mg, 25mg

Active ingredient

Pack

120 pills, 180 pills, 270 pills, 30 pills, 360 pills, 60 pills, 90 pills

2 reviews for Aldactone

  1. Rated 4 out of 5

    Lucas (verified owner)

    Product was well-protected.

  2. Rated 5 out of 5

    Greyson “Grey” Foster (verified owner)

    Customer service went above and beyond when I had a question about a medication change. They connected me with a pharmacist who provided detailed, personalized advice.

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Aldactone
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