A new report from the World Health Organization (WHO) reveals that over one billion people worldwide suffer from mental health conditions like anxiety and depression. These conditions are now the second leading cause of long-term disability. The WHO also warns about the high suicide rate—727,000 deaths in 2021—and the massive economic burden, costing the global economy $1 trillion each year. The organization is calling for urgent action, including better access to mental health care and more investment in treatments. Pharmacists play a key role in providing medications and support for patients with mental health conditions. While there are many approved drugs for depression, treatment-resistant cases remain a challenge. New treatments, including psychedelic-based therapies, are being studied, but approvals are still limited. The WHO emphasizes the need for stronger prevention strategies and better access to care to address this growing global issue.